2.Pathogenesis
3.Clinical Manifestations
4.Laboratory Evaluation
5.Differential Diagnosis
6.Clinical Course
7.Treatment
stress : major factor
smoking : minor factor
(major risk of Opthalmopathy)
Genetic : HLA-DR, CTCA-4, PTPN22
monozygotic twins : 20~30%
dizygotic : 5%
Sudden iodine intake
Postpartum : 3배
TSI Hyperthyroidism
detected by TBII assay (특히 임산부 Graves’ dis.에서 high TSI monitoring, TSI는 태반 넘어가 neonatal thyrotoxicosis)
TBII 존재는 TSI 있음을 시사
TPO Ab. : marker of autoimmunity
NO SPECS
0 = No signs or Sx.
1 = Only signs, no Sx.
2 = Soft tissue involvement
3 = Proptosis (>22mm)
4 = Extraocular m. involvement
5 = Corneal involvement
6 = Sight Loss
Gregory A. Brent. Graves’ Disease. N Engl J Med 2008;358:2594-605.
Rebecca S. Bahn. Graves’ Ophthalmopathy. N Engl J Med 2010;362:726-38.

분야