We have also shown that RhoA interacts directly with PKC-α in vitro.
1) In human endothelial cells, activation of ROCK by RhoA requires PKC activation .
(1998,Hippenstiel S et al)
2) We have recently shown that preincubation of SMCs with Y-27632(specific ROCKII inhibitor), partially inhibited contraction(~50%) concomitant with inhibition of association of ROCKII with HSP27 in the particulate fraction .(2004,Patil SB, et al)
The aims of the studies were to investigate
the agonist-induced possible association and
translocation of MYPT with HSP27 and to
examine the roles played by RhoA and PKC
pathways in the regulation of MLCP activity.
(Suresh B. Patil and Khalil N. Bitar)
PPT에 발표 스크립트도 포함되어 있습니다.
논문읽고 발표수업 하실 때 참고하시면 많은 도움 되실겁니다.

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