2. 투여용량과 기간
3. BBB 통과
4. Side effect
Herrison’s international medicine, fauci
Cecil medicine 23th edition, goldman& ausiello
POWER manual series 18th edition
이 환자는 결핵성 수막염(Tuberculous meningitis)로 추정
치료
1. BBB를 통과하는 항결핵제와
: isoniazid, rifampicin, pyrazinamide and ethambutol for two months, followed by isoniazid and rifampicin alone for a further ten months
2. 스테로이드(dexamethasone)을 병용
: Steroids are always used in the first six weeks of treatment (and sometimes for longer)
Pleurisy(흉막염): prednisolone 20 to 40 mg daily tapered off over 4 to 8 weeks
Extremely advanced TB: 40 to 60 mg daily tapered off over 4 to 8 weeks
TB in children: 2 to 5 mg/kg/day for one week, 1 mg/kg/day the next week, then tapered off over 5 weeks
Steroids may be of benefit in peritonitis, miliary disease, laryngeal TB, lymphadenitis and genitourinary disease
routine use of steroids cannot be recommended.
-> should be considered by the attending physician.
Thalidomide may be of benefit in TB meningitis and has been used in cases where patients have failed to respond to steroid treatment

분야