CCR5 antagonist
Drug development
SAR
New drug design
C-C chemokine receptor type 5, also known as CCR5 or CD195
protein on the surface of white blood cells that is involved in the immune system
the process by which T cells are attracted to specific tissue and organ targets
Many forms of HIV, the virus that causes AIDS, initially use CCR5 to enter and infect host cells
CCR5의 기능
belongs to the beta chemokine receptors family of integral membrane proteins.
G protein-coupled receptor
The natural chemokine ligands : RANTES and MIP 1α and 1β .It also interacts with CCL3L1.
T cells, macrophages, dendritic cells and microglia
inflammatory responses to infection

분야